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Third, TMAO increases circulating pro-inflammatory chemokines and cytokines, which are known to lead to the progression of heart failure [1, 47, 48]

We need much bigger, better-designed studies before we can call this a proven treatment

The average time to diagnose IC is approximately 2 years, because it mimics recurrent bladder infections

Emerging microfluidic platforms enable co-encapsulation of probiotics with prebiotics (e.g., alginateinulin hydrogels) within microparticles, conferring resistance to gastrointestinal stress, promoting colonic retention, and supporting in situ short-chain fatty acid fermentation, thereby augmenting anti-inflammatory effects (Yin et al., 2024)

doi:10.1016/S0015-6264(75)80004-6.[Crossref], [PubMed] , [Google Scholar]) who provided rats with drinking water that contained low levels of PGN (0.25% and 0.5%)